Barcelona will once again take on a side in the Champions League who bring back good memories.
The Blaugrana won the 2009 Champions League final 2-0 against Manchester United, and followed that up with a 3-1 victory over the same opponent in 2011.
However the Camp Nou also invokes good memories for Ole Gunnar Solskjaer, United's head coach, as his 93rd minute goal, after Teddy Sheringham's 91st minute leveller, won the Red Devils the 1999 Champions League final.
Now on the dugout, he will look to eliminate the Blaugrana after resurrecting the fortunes of United.
We look at the main dangers United pose to the Azulgrana.
Powerful in the air
If there is any area where United may have the edge, it is in height.
Chris Smalling and Nemanja Matic are both 1.94 metres tall, Scott McTominay comes in at 1.93m, Paul Pogba is 1.91m, Romelu Lukaku is 1.90m, David de Gea stands at 1.89m, Victor Lindelof is 1.87m, along with Eric Bailly, while Marcus Rashford stands at 1.85m.
This superiority isn't being translated into goals, though, and surprisingly they only have five goals across all competitions from headers.
Still, Barcelona next to be attentive.
They feel 'invincible'
The victory at the Parc des Princes, with 10 injured players and having to overcome a 2-0 deficit, has been a tremendous boost to the confidence of the club.
Since the arrival of Solskjaer, the players have felt almost invincible and the numbers reflect it.
In 18 games in charge, he has overseen 14 wins